Linked Life Data

16790793

Source:http://linkedlifedata.com/resource/pubmed/id/16790793

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-6-22
pubmed:abstractText
Adjuvant-induced survival of T cells after antigen activation correlates with increased expression of Bcl-3. Bcl-3 is an NF-kappaB/IkappaB family member and has been implicated in transcriptional regulation in several cell types. We tested the ability of mice deficient in Bcl-3 (Bcl-3 KO) to exhibit T-cell adjuvant-induced survival after challenge with the superantigen staphylococcal enterotoxin B (SEB), using lipopolysaccharide (LPS) as a natural adjuvant. These studies showed that Bcl-3 is required for secondary gamma interferon (IFN-gamma) production by CD8 T cells but not for adjuvant-induced survival effects. Specifically, wild-type and Bcl-3 KO mice exhibited comparable long-term increases in the Vbeta8(+) T-cell populations, indicating no lack of survival in response to adjuvant stimulation in the Bcl-3 KO activated T cells. Ectopic expression of the Bcl-3-related molecules IkappaBalpha, IkappaBbeta, and IkappaBepsilon in SEB-activated T cells increased survival during in vitro culture in the absence of adjuvant, suggesting that these IkappaB molecules could exert a survival function in antigen-activated T cells in place of Bcl-3. However, Vbeta8(+) CD8 T cells from SEB- plus LPS-treated Bcl-3 KO mice produced less IFN-gamma upon in vitro restimulation than Vbeta8(+) CD8 T cells from wild-type mice. Therefore, Bcl-3 plays a unique role in the regulation of IFN-gamma production in this model system.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-10209051, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-10570287, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-10928279, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-11323692, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-11970979, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-12055628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-12538159, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-12538160, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-12808109, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-14605368, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-14657380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-14665694, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-14668329, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-14983028, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-15294939, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-15465827, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-15627613, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-15634875, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-15838378, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16025119, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16081776, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16148099, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16306601, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16325488, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-16455974, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-2970670, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-3122218, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-6850608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-7535182, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-7889419, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-8972200, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9009202, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9133427, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9135156, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9144484, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9290956, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9432980, http://linkedlifedata.com/resource/pubmed/commentcorrection/16790793-9620550
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4180-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen.
pubmed:affiliation
Institute for Cellular Therapeutics, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural