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pubmed-article:16789992pubmed:abstractTextThe study of biodistribution and in situ pharmacokinetics is a challenging, but sometimes very important, aspect of premarketing characterization of drugs. We aimed to develop a non-invasive fluorine magnetic resonance (MR) spectroscopic method for the absolute quantitation of a mono-fluorinated compound and of its metabolites in the heart and liver of healthy subjects for this purpose.lld:pubmed
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pubmed-article:16789992pubmed:articleTitleMagnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole.lld:pubmed
pubmed-article:16789992pubmed:affiliationSciTrials, LLC, Westwood, MA 02090, USA. erikaschneider@comcast.netlld:pubmed
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