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rdf:type |
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lifeskim:mentions |
umls-concept:C0018787,
umls-concept:C0023884,
umls-concept:C0024487,
umls-concept:C0031327,
umls-concept:C0205198,
umls-concept:C0444498,
umls-concept:C0539969,
umls-concept:C0743223,
umls-concept:C1261322,
umls-concept:C1515655,
umls-concept:C1519941
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pubmed:issue |
3
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
The study of biodistribution and in situ pharmacokinetics is a challenging, but sometimes very important, aspect of premarketing characterization of drugs. We aimed to develop a non-invasive fluorine magnetic resonance (MR) spectroscopic method for the absolute quantitation of a mono-fluorinated compound and of its metabolites in the heart and liver of healthy subjects for this purpose.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0269-4727
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pubmed:author |
pubmed-author:BleyM AMA,
pubmed-author:FrederickBB,
pubmed-author:HashoianRR,
pubmed-author:HirashimaFF,
pubmed-author:HsuRR,
pubmed-author:HwangJJ,
pubmed-author:JonesSS,
pubmed-author:KochPP,
pubmed-author:LyooI KIK,
pubmed-author:MaierGG,
pubmed-author:NassarLL,
pubmed-author:RenshawP FPF,
pubmed-author:SchneiderEE,
pubmed-author:SungYY,
pubmed-author:VillafuerteR ARA,
pubmed-author:WilkinsonSS
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-73
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pubmed:dateRevised |
2008-5-28
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pubmed:meshHeading |
pubmed-meshheading:16789992-Adult,
pubmed-meshheading:16789992-Animals,
pubmed-meshheading:16789992-Anti-Allergic Agents,
pubmed-meshheading:16789992-Benzimidazoles,
pubmed-meshheading:16789992-Chromatography, High Pressure Liquid,
pubmed-meshheading:16789992-Dogs,
pubmed-meshheading:16789992-Dose-Response Relationship, Drug,
pubmed-meshheading:16789992-Echo-Planar Imaging,
pubmed-meshheading:16789992-Female,
pubmed-meshheading:16789992-Fluorine Compounds,
pubmed-meshheading:16789992-Fluorine Radioisotopes,
pubmed-meshheading:16789992-Half-Life,
pubmed-meshheading:16789992-Humans,
pubmed-meshheading:16789992-Liver,
pubmed-meshheading:16789992-Magnetic Resonance Spectroscopy,
pubmed-meshheading:16789992-Male,
pubmed-meshheading:16789992-Middle Aged,
pubmed-meshheading:16789992-Myocardium,
pubmed-meshheading:16789992-Piperidines,
pubmed-meshheading:16789992-Reproducibility of Results,
pubmed-meshheading:16789992-Tissue Distribution
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pubmed:year |
2006
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pubmed:articleTitle |
Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole.
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pubmed:affiliation |
SciTrials, LLC, Westwood, MA 02090, USA. erikaschneider@comcast.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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