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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with nondetectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0003-9896
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pubmed:author |
pubmed-author:BeyeaJanJ,
pubmed-author:BrittonJulie AJA,
pubmed-author:EngSybil MSM,
pubmed-author:GammonMarilie DMD,
pubmed-author:GaudetMia MMM,
pubmed-author:HatchMaureenM,
pubmed-author:KabatGeoffrey CGC,
pubmed-author:LevinBruceB,
pubmed-author:NeugutAlfred IAI,
pubmed-author:SagivSharon KSK,
pubmed-author:SantellaRegina MRM,
pubmed-author:ShantakumarSumitraS,
pubmed-author:StellmanSteve DSD,
pubmed-author:TeitelbaumSusan LSL,
pubmed-author:TerryMary BethMB,
pubmed-author:WangLian WenLW,
pubmed-author:WangQiaoQ,
pubmed-author:WolffMary SMS
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
640-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16789472-Aged,
pubmed-meshheading:16789472-Breast Neoplasms,
pubmed-meshheading:16789472-Case-Control Studies,
pubmed-meshheading:16789472-DNA Adducts,
pubmed-meshheading:16789472-Disease Susceptibility,
pubmed-meshheading:16789472-Environmental Exposure,
pubmed-meshheading:16789472-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16789472-Epidemiologic Studies,
pubmed-meshheading:16789472-Female,
pubmed-meshheading:16789472-Humans,
pubmed-meshheading:16789472-Incidence,
pubmed-meshheading:16789472-Middle Aged,
pubmed-meshheading:16789472-Polycyclic Hydrocarbons, Aromatic,
pubmed-meshheading:16789472-Population Surveillance,
pubmed-meshheading:16789472-Risk Assessment,
pubmed-meshheading:16789472-Risk Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis.
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pubmed:affiliation |
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599-7435, USA. gammon@unc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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