|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-6-20
|
|
pubmed:abstractText |
Mucosal tissues require constant immune surveillance to clear harmful pathogens while maintaining tolerance to self Ags. Regulatory T cells (Tregs) play a central role in this process and expression of alpha(E)beta(7) has been reported to define a subset of Tregs with tropism for inflamed tissues. However, the signals responsible for recruiting Tregs to epithelial surfaces are poorly understood. We have isolated a subset of CCR10-expressing CD25+CD4+Foxp3+ Tregs with potent anti-inflammatory properties from chronically inflamed human liver. The CCR10+ Tregs were detected around bile ducts that expressed increased levels of the CCR10 ligand CCL28. CCL28 was secreted by primary human cholangiocytes in vitro in response to LPS, IL-1beta, or bile acids. Exposure of CCR10+ Tregs to CCL28 in vitro stimulated migration and adhesion to mucosal addressin cell adhesion molecule-1 and VCAM-1. Liver-derived CCR10+ Tregs expressed low levels of CCR7 but high levels of CXCR3, a chemokine receptor associated with infiltration into inflamed tissue and contained a subset of alpha(E)beta7(+) cells. We propose that CXCR3 promotes the recruitment of Tregs to inflamed tissues and CCR10 allows them to respond to CCL28 secreted by epithelial cells resulting in the accumulation of CCR10+ Tregs at mucosal surfaces.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL28 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR10,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
177
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
593-603
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16785557-Bile Ducts,
pubmed-meshheading:16785557-Cells, Cultured,
pubmed-meshheading:16785557-Chemokines,
pubmed-meshheading:16785557-Chemokines, CC,
pubmed-meshheading:16785557-Chemotaxis, Leukocyte,
pubmed-meshheading:16785557-Cholangitis, Sclerosing,
pubmed-meshheading:16785557-Chronic Disease,
pubmed-meshheading:16785557-Epithelial Cells,
pubmed-meshheading:16785557-Forkhead Transcription Factors,
pubmed-meshheading:16785557-Humans,
pubmed-meshheading:16785557-Immunity, Mucosal,
pubmed-meshheading:16785557-Inflammation Mediators,
pubmed-meshheading:16785557-Interleukin-1,
pubmed-meshheading:16785557-Interleukin-10,
pubmed-meshheading:16785557-Lipopolysaccharides,
pubmed-meshheading:16785557-Liver Cirrhosis, Biliary,
pubmed-meshheading:16785557-Liver Diseases, Alcoholic,
pubmed-meshheading:16785557-Receptors, CCR10,
pubmed-meshheading:16785557-Receptors, CCR7,
pubmed-meshheading:16785557-Receptors, CXCR3,
pubmed-meshheading:16785557-Receptors, Chemokine,
pubmed-meshheading:16785557-T-Lymphocyte Subsets,
pubmed-meshheading:16785557-T-Lymphocytes, Regulatory,
pubmed-meshheading:16785557-Up-Regulation
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
|
|
pubmed:affiliation |
Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
