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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033554,
umls-concept:C0039194,
umls-concept:C0039198,
umls-concept:C0387583,
umls-concept:C0441712,
umls-concept:C1171362,
umls-concept:C1332714,
umls-concept:C1334114,
umls-concept:C1416467,
umls-concept:C1515670
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-20
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pubmed:abstractText |
CD4+CD25+ regulatory T (T(R)) cells suppress effector T cells by partly unknown mechanisms. In this study, we describe a population of human suppressive CD4+CD25+ adaptive T(R) (T(R)(adapt)) cells induced in vitro that express cyclooxygenase 2 (COX-2) and the transcription factor FOXP3. T(R)(adapt) cells produce PGE(2) and suppress effector T cell responses in a manner that is reversed by COX inhibitors and PGE(2) receptor-specific antagonists. In resting CD4+CD25- T cells, treatment with PGE(2) induced FOXP3 expression. Thus, autocrine and paracrine effects of PGE(2) produced by COX-2-positive T(R)(adapt) cells may be responsible for both the FOXP3+ phenotype and the mechanism used by these cells to suppress effector T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-54
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16785520-Cell Communication,
pubmed-meshheading:16785520-Cells, Cultured,
pubmed-meshheading:16785520-Cyclic AMP,
pubmed-meshheading:16785520-Cyclooxygenase 2,
pubmed-meshheading:16785520-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:16785520-Dinoprostone,
pubmed-meshheading:16785520-Enterotoxins,
pubmed-meshheading:16785520-Forkhead Transcription Factors,
pubmed-meshheading:16785520-Humans,
pubmed-meshheading:16785520-Immunity, Innate,
pubmed-meshheading:16785520-Immunosuppressive Agents,
pubmed-meshheading:16785520-Lymphocyte Activation,
pubmed-meshheading:16785520-Prostaglandin Antagonists,
pubmed-meshheading:16785520-Receptors, Interleukin-2,
pubmed-meshheading:16785520-Receptors, Prostaglandin E,
pubmed-meshheading:16785520-T-Lymphocyte Subsets,
pubmed-meshheading:16785520-T-Lymphocytes, Regulatory
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pubmed:year |
2006
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pubmed:articleTitle |
FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism.
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pubmed:affiliation |
The Biotechnology Centre, Ullevaal University Hospital, University of Oslo, N-0317 Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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