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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-20
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pubmed:abstractText |
IL-18 induces inflammation resulting in either enhanced protection from pathogens or exacerbation of autoimmunity, and T cells are profoundly activated during these responses. How IL-18 influences T cell activation is unknown, but this study in mice shows that IL-18 boosted Ag-specific T cell clonal expansion of effector T cells and induced a subpopulation of IFN-gamma superproducing T cells. Commitment to IFN-gamma production through IL-18 was independent of NK cells and IL-12 but dependent on host-derived IFN-gamma. To determine how expansion of these effectors occurred, IL-18 was shown to induce OX40L on dendritic cells, whereas peptide stimulation induced CD134 (OX40) on specific T cells. CD134 blockade inhibited T cell effector expansion thereby reducing the number of IFN-gamma superproducers by 12-fold. Thus, independent of IL-12, IL-18 impacts T cell immunity throughout lymphoid and nonlymphoid tissue by bridging the innate and adaptive arms of the immune system through IFN-gamma and the CD134 costimulatory pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Il18r1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-45
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:16785519-Adjuvants, Immunologic,
pubmed-meshheading:16785519-Adoptive Transfer,
pubmed-meshheading:16785519-Animals,
pubmed-meshheading:16785519-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16785519-Cells, Cultured,
pubmed-meshheading:16785519-Epitopes, T-Lymphocyte,
pubmed-meshheading:16785519-Immunity, Cellular,
pubmed-meshheading:16785519-Immunity, Innate,
pubmed-meshheading:16785519-Interferon-gamma,
pubmed-meshheading:16785519-Interleukin-12,
pubmed-meshheading:16785519-Interleukin-18,
pubmed-meshheading:16785519-Interleukin-18 Receptor alpha Subunit,
pubmed-meshheading:16785519-Killer Cells, Natural,
pubmed-meshheading:16785519-Lymph Nodes,
pubmed-meshheading:16785519-Mice,
pubmed-meshheading:16785519-Mice, Inbred C57BL,
pubmed-meshheading:16785519-Mice, Knockout,
pubmed-meshheading:16785519-Mice, Transgenic,
pubmed-meshheading:16785519-Receptors, Interleukin,
pubmed-meshheading:16785519-Receptors, Interleukin-18,
pubmed-meshheading:16785519-Receptors, OX40,
pubmed-meshheading:16785519-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16785519-Signal Transduction,
pubmed-meshheading:16785519-Spleen
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pubmed:year |
2006
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pubmed:articleTitle |
IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway.
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pubmed:affiliation |
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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