Source:http://linkedlifedata.com/resource/pubmed/id/16784851
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
17
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pubmed:dateCreated |
2006-7-31
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pubmed:abstractText |
A cyclic octapeptide, cyclosquamosin B (2), isolated from the seeds of Annona squamosa showed a vasorelaxant effect on rat aorta. It showed a slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with/without endothelium. It showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, but moderately inhibition effect on NE-induced contraction in the presence of nicardipine. These results showed that the vasorelaxant effect by 2 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4609-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16784851-Animals,
pubmed-meshheading:16784851-Annona,
pubmed-meshheading:16784851-Aorta,
pubmed-meshheading:16784851-Calcium,
pubmed-meshheading:16784851-Molecular Structure,
pubmed-meshheading:16784851-Peptides, Cyclic,
pubmed-meshheading:16784851-Plant Extracts,
pubmed-meshheading:16784851-Rats,
pubmed-meshheading:16784851-Seeds,
pubmed-meshheading:16784851-Vasodilation
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pubmed:year |
2006
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pubmed:articleTitle |
Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. moritah@hoshi.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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