16784850

Source:http://linkedlifedata.com/resource/pubmed/id/16784850

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003015, umls-concept:C0205314, umls-concept:C0220781, umls-concept:C0243071, umls-concept:C0679622, umls-concept:C1883254
pubmed:issue	17
pubmed:dateCreated	2006-7-31
pubmed:abstractText	Novel analogues of the angiotensin I-converting enzyme (ACE) inhibitor keto-ACE were synthesized via a facile Horner-Emmons olefination of a phosphonoketone precursor with ethyl glyoxylate. Introduction of a bulky aromatic tryptophan at the P(2)(') position of keto-ACE resulted in a significant increase in C-domain-selectivity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme..., http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0960-894X
pubmed:author	pubmed-author:ChibaleKellyK, pubmed-author:NchindaAloysius TAT, pubmed-author:RedelinghuysPierreP, pubmed-author:SturrockEdward DED
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4612-5
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16784850-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:16784850-Molecular Structure, pubmed-meshheading:16784850-Peptidyl-Dipeptidase A, pubmed-meshheading:16784850-Structure-Activity Relationship
pubmed:year	2006
pubmed:articleTitle	Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.
pubmed:affiliation	Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't