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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0005558,
umls-concept:C0006142,
umls-concept:C0031809,
umls-concept:C0033572,
umls-concept:C0205210,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C1101610,
umls-concept:C1513400,
umls-concept:C1999230
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pubmed:dateCreated |
2006-9-11
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pubmed:abstractText |
Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However, previously reported methods for measuring miRNA expression consume large amounts of tissue, prohibiting high-throughput miRNA profiling from typically small clinical samples such as excision or core needle biopsies of breast or prostate cancer. Here we describe a novel combination of linear amplification and labeling of miRNA for highly sensitive expression microarray profiling requiring only picogram quantities of purified microRNA.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-10642801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-10706289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11015604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11309499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11452083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11553815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11679670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11679671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-11679672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12624257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12672692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12805599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12809598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12869753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-12941428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-14744438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15210942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15212585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15345052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15469607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15574827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15598818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15684409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15782179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-15944708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16000569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16103053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16177135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16244135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16314309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16452179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-16540696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-8252622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-9092624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-9843981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16784538-9915493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16784538-Biopsy,
pubmed-meshheading:16784538-Breast Neoplasms,
pubmed-meshheading:16784538-Cluster Analysis,
pubmed-meshheading:16784538-Female,
pubmed-meshheading:16784538-Gene Expression Profiling,
pubmed-meshheading:16784538-Genes, erbB-2,
pubmed-meshheading:16784538-Humans,
pubmed-meshheading:16784538-Male,
pubmed-meshheading:16784538-MicroRNAs,
pubmed-meshheading:16784538-Phenotype,
pubmed-meshheading:16784538-Prostatic Neoplasms,
pubmed-meshheading:16784538-Receptors, Estrogen,
pubmed-meshheading:16784538-Reproducibility of Results,
pubmed-meshheading:16784538-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16784538-Sensitivity and Specificity,
pubmed-meshheading:16784538-Tumor Cells, Cultured,
pubmed-meshheading:16784538-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies.
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pubmed:affiliation |
UCSF Comprehensive Cancer Center, Department of Urology, San Francisco, California 94115, USA. michael.d.mattie@gsk.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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