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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-7-25
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pubmed:abstractText |
Polyozellin, isolated from Polyozellus multiplex (Thelephoraceae), was investigated for its anti-inflammatory activity in the murine macrophage cell line RAW 264.7. Polyozellin inhibited both lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) gene expression in a dose-dependent manner. The effects of polyozellin on the activation of nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein (MAP) kinases in these cells were studied in order to elucidate the underlying mechanism. Polyozellin suppressed the activation of both LPS-induced NF-kappaB and the stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), but had no effect on the extracellular signal-regulated kinase (ERK) or p38. These data suggest that polyozellin suppresses iNOS expression by inhibiting the activation of NF-kappaB and SAPK/JNK, leading to the inhibition of NO production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0032-0943
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
857-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16783701-Animals,
pubmed-meshheading:16783701-Anti-Inflammatory Agents,
pubmed-meshheading:16783701-Basidiomycota,
pubmed-meshheading:16783701-Cell Line,
pubmed-meshheading:16783701-Down-Regulation,
pubmed-meshheading:16783701-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:16783701-Furans,
pubmed-meshheading:16783701-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:16783701-Lipopolysaccharides,
pubmed-meshheading:16783701-Mice,
pubmed-meshheading:16783701-NF-kappa B,
pubmed-meshheading:16783701-Nitric Oxide,
pubmed-meshheading:16783701-Nitric Oxide Synthase Type II,
pubmed-meshheading:16783701-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Polyozellin inhibits nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and SAPK/JNK in RAW 264.7 cells.
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pubmed:affiliation |
College of Pharmacy, Medicinal Resources Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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