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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2006-6-19
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pubmed:abstractText |
The INT-0098 Intergroup Liver Tumor Study demonstrated no statistically significant differences in event-free and overall survival between patients randomized to treatment with either cisplatin + fluorouracil + vincristine (C5V) or cisplatin + doxorubicin. Results from this and other therapeutic trials suggested that cisplatin was the most active agent against hepatoblastoma. To increase the platinum dose-intensity, a novel regimen was developed alternating carboplatin and cisplatin (CC) every 2 weeks. The P9645 study was designed to compare the risk of treatment failure for patients with stage III/IV hepatoblastoma randomized to either C5V or CC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:BowmanLauraL,
pubmed-author:CastleberryRobert PRP,
pubmed-author:ChenZhengjiaZ,
pubmed-author:FinegoldMiltonM,
pubmed-author:GreffeBrianB,
pubmed-author:KatzensteinHowardH,
pubmed-author:KrailoMark DMD,
pubmed-author:LondonWendy BWB,
pubmed-author:MalogolowkinMarcio HMH,
pubmed-author:NewmanKurtK,
pubmed-author:ReynoldsMarletaM,
pubmed-author:RowlandJonJ,
pubmed-author:WomerRichard BRB
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2879-84
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pubmed:meshHeading |
pubmed-meshheading:16782927-Adolescent,
pubmed-meshheading:16782927-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16782927-Carboplatin,
pubmed-meshheading:16782927-Child,
pubmed-meshheading:16782927-Child, Preschool,
pubmed-meshheading:16782927-Cisplatin,
pubmed-meshheading:16782927-Female,
pubmed-meshheading:16782927-Fluorouracil,
pubmed-meshheading:16782927-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:16782927-Hepatoblastoma,
pubmed-meshheading:16782927-Humans,
pubmed-meshheading:16782927-Infant,
pubmed-meshheading:16782927-Liver Neoplasms,
pubmed-meshheading:16782927-Male,
pubmed-meshheading:16782927-Vincristine
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pubmed:year |
2006
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pubmed:articleTitle |
Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma.
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pubmed:affiliation |
Childrens Hospital Los Angeles, Division of Hematology-Oncology, Los Angeles, CA 90027, USA. mmalogolowkin@chla.usc.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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