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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-9-13
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pubmed:abstractText |
1. In two separate studies, each with 12 healthy male volunteers, the pharmacokinetic and dynamic properties of a transdermal delivery system for bopindolol were evaluated. 2. In study I it was shown that bopindolol absorption from a 14 mg patch occurred over the whole 7-day application period. No signs of a significant skin depot were found. 3. In study II, a linear pharmacokinetic behaviour but a non-linear kinetic/dynamic relationship was established for the patches over a dose range from 7 to 21 mg. Comparable peak effects of reduction in exercise-induced tachycardia were observed after different patch doses and an i.v. injection. However, the effect was significantly prolonged with the patches compared with the injection and was maintained over 7 days. 4. The patches showed a good local and systemic tolerability in both studies over a dosing interval of up to 7 days.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-2341539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-2565958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-2581075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-2889554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-3028816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-3119815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-4028622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-4155170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-6106456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-6329585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-641805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1678271-761446
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
671-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1678271-Administration, Cutaneous,
pubmed-meshheading:1678271-Adrenergic beta-Antagonists,
pubmed-meshheading:1678271-Adult,
pubmed-meshheading:1678271-Analysis of Variance,
pubmed-meshheading:1678271-Exercise Test,
pubmed-meshheading:1678271-Humans,
pubmed-meshheading:1678271-Injections, Intravenous,
pubmed-meshheading:1678271-Male,
pubmed-meshheading:1678271-Pindolol,
pubmed-meshheading:1678271-Random Allocation,
pubmed-meshheading:1678271-Reference Values
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pubmed:year |
1991
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pubmed:articleTitle |
Pharmacokinetics and pharmacodynamics of a new transdermal delivery system for bopindolol.
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pubmed:affiliation |
Department of Anaesthesia, University of Basel/Kantonsspital, Switzerland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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