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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-25
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pubmed:abstractText |
We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to the synthetic cannabinoid agonist WIN 55212-2, but not its inactive enantiomer (WIN 55212-3). The withdrawal from WIN 55212-2 was manifested as a significant (P < 0.05) decrease in the rate of planarian spontaneous locomotor activity over a 5-min observation period, using a recently designed metric (pLMV). We also report that withdrawal from cocaine (80 microM) or WIN 55212-2 (10 microM) was attenuated by the selective inhibitor of nitric oxide synthesis L-NAME (L-nitro-arginine methyl ester), which had no effect of its own on pLMV. These results suggest a common NO-dependent pathway of withdrawal from cocaine and WIN 55212-2 in Planaria.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
1099
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16782070-Analysis of Variance,
pubmed-meshheading:16782070-Anesthetics, Local,
pubmed-meshheading:16782070-Animals,
pubmed-meshheading:16782070-Behavior, Animal,
pubmed-meshheading:16782070-Benzoxazines,
pubmed-meshheading:16782070-Cannabinoids,
pubmed-meshheading:16782070-Cocaine,
pubmed-meshheading:16782070-Disease Models, Animal,
pubmed-meshheading:16782070-Dose-Response Relationship, Drug,
pubmed-meshheading:16782070-Drug Interactions,
pubmed-meshheading:16782070-Enzyme Inhibitors,
pubmed-meshheading:16782070-Morpholines,
pubmed-meshheading:16782070-Motor Activity,
pubmed-meshheading:16782070-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:16782070-Naphthalenes,
pubmed-meshheading:16782070-Planarians,
pubmed-meshheading:16782070-Substance Withdrawal Syndrome,
pubmed-meshheading:16782070-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria.
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pubmed:affiliation |
Temple University School of Pharmacy, Philadelphia, PA 19140, USA. scott.rawls@temple.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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