Source:http://linkedlifedata.com/resource/pubmed/id/16780946
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-7-24
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| pubmed:abstractText |
Periodic behavioral motor patterns are normally controlled by neural circuits, such as central pattern generators. We here report a novel mechanism of motor pattern generation by non-neural cells. The defecation motor program in Caenorhabditis elegans consists of three stereotyped motor steps with precise timing and this behavior has been studied as a model system of a ultradian biological clock [J.H. Thomas, Genetic analysis of defecation in C. elegans, Genetics 124 (1990) 855-872; D.W. Liu, J.H. Thomas, Regulation of a periodic motor program in C. elegans, J. Neurosci. 14 (1994) 1953-1962; K. Iwasaki, D.W. Liu, J.H. Thomas, Genes that control a temperature-compensated ultradian clock in Caenorhabditis elegans, Proc. Natl. Acad. Sci. USA 92 (1995), 10317-10321]. It was previously implied that the inositol-1,4,5-trisphosphate (IP3) receptor in the intestine was necessary for this periodic behavior [P. Dal Santo, M.A. Logan, A.D. Chisholm, E.M. Jorgensen, The inositol trisphosphate receptor regulates a 50s behavioral rhythm in C. elegans, Cell 98 (1999) 757-767]. Therefore, we developed a new assay system to study a relationship between this behavioral timing and intestinal Ca(2+) dynamics. Using this assay system, we found that the timing between the first and second motor steps is coordinated by intercellular Ca(2+)-wave propagation in the intestine. Lack of the Ca(2+)-wave propagation correlated with no coordination of the motor steps in the CaMKII mutant. Also, when the Ca(2+)-wave propagation was blocked by the IP3 receptor inhibitor heparin at the mid-intestine in wild type, the second/third motor steps were eliminated, which phenocopied ablation of the motor neurons AVL and DVB. These observations suggest that an intestinal Ca(2+)-wave propagation governs the timing of neural activities that controls specific behavioral patterns in C. elegans.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0143-4160
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
319-27
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| pubmed:dateRevised |
2007-7-18
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| pubmed:meshHeading |
pubmed-meshheading:16780946-Animals,
pubmed-meshheading:16780946-Caenorhabditis elegans,
pubmed-meshheading:16780946-Calcium Channels,
pubmed-meshheading:16780946-Calcium Signaling,
pubmed-meshheading:16780946-Defecation,
pubmed-meshheading:16780946-Heparin,
pubmed-meshheading:16780946-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:16780946-Intestines,
pubmed-meshheading:16780946-Motor Activity,
pubmed-meshheading:16780946-Motor Neurons,
pubmed-meshheading:16780946-Muscle Contraction,
pubmed-meshheading:16780946-Receptors, Cytoplasmic and Nuclear
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Intestinal calcium waves coordinate a behavioral motor program in C. elegans.
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| pubmed:affiliation |
Department of Molecular Pharmacology & Biological Chemistry, Institute for Neuroscience, Northwestern University Medical School, 303 E. Chicago Avenue, Searle 5-551, Chicago, IL 60611, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|