Source:http://linkedlifedata.com/resource/pubmed/id/16780889
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
2006-11-3
|
pubmed:abstractText |
Disorders associated with fragile X syndrome involve a trinucleotide (CGG) repeat expansion in the FMR1 gene. Recently, a progressive movement disorder (fragile X-associated tremor/ataxia syndrome [FXTAS]) has been identified in premutation carriers, persons with 55 to 200 CGG repeats. In addition to ataxia, action tremor, and Parkinsonism, early case reports suggested that FXTAS involves impaired cognition, but the precise nature of the impairment has not been elucidated. In this first, preliminary study of the subject, circumscribed aspects of cognitive functioning were examined in 25 men with FXTAS. Subjects' performance on the cognitive tests was compared with normative data. Scores on two measures of executive cognitive functioning showed a high prevalence of substantial impairment. Capacity for inhibition was severely affected in one-quarter of this highly educated sample; information processing speed was profoundly impaired in most subjects. Although mean verbal and performance IQ scores were not significantly different from the general population, they were quite low given the sample's educational level. Cognitive and functional impairment was greater for men with more CGG repeats, although number of repeats was not associated with age of onset of either tremor or ataxia. The results provide evidence that FXTAS involves marked impairment of executive cognitive abilities.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-510X
|
pubmed:author |
pubmed-author:BregaAngela GAG,
pubmed-author:CogswellJennifer BJB,
pubmed-author:EpsteinJenniferJ,
pubmed-author:GoodrichGlenn KGK,
pubmed-author:GrigsbyJimJ,
pubmed-author:HagermanPaul JPJ,
pubmed-author:HagermanRandi JRJ,
pubmed-author:JacquemontSébastienS,
pubmed-author:JardiniTristanT,
pubmed-author:LeeheyMaureen AMA,
pubmed-author:LoeschDanuta ZDZ,
pubmed-author:TassoneFloraF,
pubmed-author:WilsonRebeccaR
|
pubmed:issnType |
Print
|
pubmed:day |
25
|
pubmed:volume |
248
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
227-33
|
pubmed:dateRevised |
2007-12-3
|
pubmed:meshHeading |
pubmed-meshheading:16780889-Aged,
pubmed-meshheading:16780889-Aged, 80 and over,
pubmed-meshheading:16780889-Cognition Disorders,
pubmed-meshheading:16780889-Fragile X Syndrome,
pubmed-meshheading:16780889-Humans,
pubmed-meshheading:16780889-Male,
pubmed-meshheading:16780889-Middle Aged,
pubmed-meshheading:16780889-Movement Disorders,
pubmed-meshheading:16780889-Neuropsychological Tests,
pubmed-meshheading:16780889-Severity of Illness Index
|
pubmed:year |
2006
|
pubmed:articleTitle |
Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS).
|
pubmed:affiliation |
Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. jim.grigsby@uchsc.edu
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|