Linked Life Data

1678031

Source:http://linkedlifedata.com/resource/pubmed/id/1678031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8747
pubmed:dateCreated
1991-9-12
pubmed:abstractText
We studied the interaction of platelets with the wall of human internal mammary arteries and saphenous veins, suspended in organ chambers for measurement of isometric tension. Vessels were obtained during coronary bypass surgery and cut into 5 mm rings; in some the endothelium was chemically removed. Rings from several patients were randomly chosen for each experiment, and in each ring six concentrations of platelets (from healthy blood donors; 1-75 x 10(3)/microliters) were tested consecutively and concentration-response curves constructed; the areas under these curves were used for statistical comparisons. In rings of internal mammary artery contracted in response to noradrenaline, aggregating platelets induced endothelium-dependent relaxation which was prevented by apyrase (0.67 U/ml ADPase activity) and L-NG-monomethylarginine (1 mmol/l). By contrast, in saphenous vein rings contracted in response to noradrenaline, aggregating platelets induced only a further increase in tension. In quiescent vessels, the platelet-induced contraction did not occur in arteries with endothelium but that in veins was greater and facilitated by endothelium. Preincubation of platelets with aspirin (10 mumol/l) reduced the contraction in both vessels, but contraction was abolished only in the presence of both the thromboxane receptor antagonist SQ-30741 and the serotoninergic (5HT2) receptor antagonist ketanserin. These findings show that platelet-derived ADP causes release of nitric oxide by the endothelium of internal mammary artery but not of saphenous vein; thromboxane A2 and serotonin mediate contraction in vein but not artery with endothelium. These differences may contribute to differences in graft function and the clinical efficacy of antiplatelet drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
337
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
939-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1678031-Apyrase, pubmed-meshheading:1678031-Arginine, pubmed-meshheading:1678031-Aspirin, pubmed-meshheading:1678031-Blood Platelets, pubmed-meshheading:1678031-Coronary Artery Bypass, pubmed-meshheading:1678031-Dose-Response Relationship, Drug, pubmed-meshheading:1678031-Endothelium, Vascular, pubmed-meshheading:1678031-Humans, pubmed-meshheading:1678031-Indomethacin, pubmed-meshheading:1678031-Isometric Contraction, pubmed-meshheading:1678031-Ketanserin, pubmed-meshheading:1678031-Mammary Arteries, pubmed-meshheading:1678031-Muscle, Smooth, Vascular, pubmed-meshheading:1678031-Norepinephrine, pubmed-meshheading:1678031-Platelet Aggregation, pubmed-meshheading:1678031-Saphenous Vein, pubmed-meshheading:1678031-Thromboxane A2, pubmed-meshheading:1678031-omega-N-Methylarginine
pubmed:year
1991
pubmed:articleTitle
Different interactions of platelets with arterial and venous coronary bypass vessels.
pubmed:affiliation
Department of Research, University Hospital, Basel, Switzerland.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, In Vitro, Randomized Controlled Trial, Research Support, Non-U.S. Gov't