|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0012200,
umls-concept:C0012854,
umls-concept:C0017262,
umls-concept:C0019145,
umls-concept:C0032136,
umls-concept:C0205263,
umls-concept:C0441889,
umls-concept:C0449468,
umls-concept:C1274040,
umls-concept:C1533685,
umls-concept:C1882695,
umls-concept:C2936194
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|
pubmed:issue |
8
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|
pubmed:dateCreated |
2006-8-23
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|
pubmed:abstractText |
Hydrodynamic injection of naked plasmid DNA (pDNA) via the tail vein is a safe and effective method of gene transfer to the liver. However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)-induced HCC model in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
8
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1018-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16779866-Alkylating Agents,
pubmed-meshheading:16779866-Animals,
pubmed-meshheading:16779866-Carcinogens,
pubmed-meshheading:16779866-Carcinoma, Hepatocellular,
pubmed-meshheading:16779866-Cytomegalovirus,
pubmed-meshheading:16779866-DNA,
pubmed-meshheading:16779866-Diethylnitrosamine,
pubmed-meshheading:16779866-Disease Models, Animal,
pubmed-meshheading:16779866-Gene Expression,
pubmed-meshheading:16779866-Gene Therapy,
pubmed-meshheading:16779866-Gene Transfer Techniques,
pubmed-meshheading:16779866-Genetic Vectors,
pubmed-meshheading:16779866-Hepatic Artery,
pubmed-meshheading:16779866-Indocyanine Green,
pubmed-meshheading:16779866-Injections, Intravenous,
pubmed-meshheading:16779866-Liver Neoplasms,
pubmed-meshheading:16779866-Male,
pubmed-meshheading:16779866-Plasmids,
pubmed-meshheading:16779866-Rats,
pubmed-meshheading:16779866-Rats, Sprague-Dawley,
pubmed-meshheading:16779866-Transgenes,
pubmed-meshheading:16779866-beta-Galactosidase
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pubmed:year |
2006
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pubmed:articleTitle |
High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine.
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pubmed:affiliation |
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho Shogoin Sakyo-ku Kyoto, 606-8507, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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