Source:http://linkedlifedata.com/resource/pubmed/id/16778130
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-7-7
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| pubmed:abstractText |
Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag SNPs captured 4 common haplotypes of the CASP1 gene. Among these, the A(in6) allele of the G+7/in6A polymorphism was less frequent in 246 cases with myocardial infarction and a parental history of disease than in 253 controls free of familial history of disease (0.13+/-0.02 versus 0.20+/-0.02; P=0.005). However, in a larger case/control study (n=1774), these effects are borderline restricted to the UK population. In a prospective cohort of 1168 patients with coronary artery disease followed up during a median period of 6.0 years, the A(in6) allele exhibited a borderline association with future cardiovascular death (hazard ratio [HR]: 0.64, 0.41 to 1.01; P=0.053) and was associated with lower serum IL-18 levels (P=0.014). Baseline caspase-1 levels in the top quartile of the distribution were predictive of cardiovascular deaths (HR=3.62, 1.81 to 7.27; P=0.0003 compared with the bottom quartile). Finally, in vitro assays of allelic imbalance showed that the CASP1 haplotype carrying the A(in6) allele was associated with a lower mRNA expression. These results indicate that caspase-1 levels are predictive of future cardiovascular death in patients with coronary artery disease. The role of CASP1 genetic variations in the susceptibility to myocardial infarction requires further investigation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1524-4571
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| pubmed:author |
pubmed-author:AtheroGene Investigators,
pubmed-author:BarbauxSandrineS,
pubmed-author:BickelChristophC,
pubmed-author:BlankenbergStefanS,
pubmed-author:CambienFrançoisF,
pubmed-author:EvansAlunA,
pubmed-author:GodefroyTiphaineT,
pubmed-author:KeeFrankF,
pubmed-author:LacknerKarl JKJ,
pubmed-author:MünzelThomasT,
pubmed-author:MorrisonCarolineC,
pubmed-author:NicaudVivianeV,
pubmed-author:PoirierOdetteO,
pubmed-author:RupprechtHans JHJ,
pubmed-author:SchnabelRenateR,
pubmed-author:TiretLaurenceL
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| pubmed:issnType |
Electronic
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| pubmed:day |
7
|
| pubmed:volume |
99
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
102-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16778130-Adult,
pubmed-meshheading:16778130-Aged,
pubmed-meshheading:16778130-Cardiovascular Diseases,
pubmed-meshheading:16778130-Case-Control Studies,
pubmed-meshheading:16778130-Caspase 1,
pubmed-meshheading:16778130-Cohort Studies,
pubmed-meshheading:16778130-Coronary Artery Disease,
pubmed-meshheading:16778130-Female,
pubmed-meshheading:16778130-Follow-Up Studies,
pubmed-meshheading:16778130-Gene Frequency,
pubmed-meshheading:16778130-Genetic Predisposition to Disease,
pubmed-meshheading:16778130-Genetic Variation,
pubmed-meshheading:16778130-Genotype,
pubmed-meshheading:16778130-Haplotypes,
pubmed-meshheading:16778130-Humans,
pubmed-meshheading:16778130-Interleukin-18,
pubmed-meshheading:16778130-Male,
pubmed-meshheading:16778130-Middle Aged,
pubmed-meshheading:16778130-Myocardial Infarction,
pubmed-meshheading:16778130-Polymorphism, Single Nucleotide,
pubmed-meshheading:16778130-Prospective Studies,
pubmed-meshheading:16778130-Risk Assessment
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| pubmed:year |
2006
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| pubmed:articleTitle |
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
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| pubmed:affiliation |
Department of Medicine II, Johannes Gutenberg-University Mainz, Mainz, Germany. blankenberg@2-med.klinik.uni-mainz.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|