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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0035647,
umls-concept:C0038952,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0334634,
umls-concept:C0599894,
umls-concept:C1417407,
umls-concept:C1521840,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
2006-6-16
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pubmed:abstractText |
To determine the methylthioadenosine phosphorylase (MTAP) gene alterations in mantle cell lymphoma (MCL) and to investigate whether the targeted inactivation of the alternative de novo AMP synthesis pathway may be a useful therapeutic strategy in tumors with inactivation of this enzyme.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BalaguéOlgaO,
pubmed-author:BoschFrancescF,
pubmed-author:ColomerDolorsD,
pubmed-author:ColomoLuisL,
pubmed-author:EstellerManelM,
pubmed-author:FragaMario FMF,
pubmed-author:HöllerSylviaS,
pubmed-author:KochM FMF,
pubmed-author:LeoniLorenzoL,
pubmed-author:MarcéSilviaS,
pubmed-author:MartinezAntonioA,
pubmed-author:MontserratEmiliE,
pubmed-author:OttGermanG,
pubmed-author:RosenwaldAndreasA,
pubmed-author:VillamorNeusN
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3754-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16778103-Base Sequence,
pubmed-meshheading:16778103-Cell Line, Tumor,
pubmed-meshheading:16778103-Chromosomes, Human, Pair 11,
pubmed-meshheading:16778103-Chromosomes, Human, Pair 14,
pubmed-meshheading:16778103-DNA Primers,
pubmed-meshheading:16778103-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:16778103-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16778103-Humans,
pubmed-meshheading:16778103-Lymphoma, Mantle-Cell,
pubmed-meshheading:16778103-Purine-Nucleoside Phosphorylase,
pubmed-meshheading:16778103-Retrospective Studies,
pubmed-meshheading:16778103-Survival Analysis,
pubmed-meshheading:16778103-Time Factors,
pubmed-meshheading:16778103-Translocation, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy.
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pubmed:affiliation |
Pathology Department, Hematopathology Unit, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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