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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-7-20
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pubmed:abstractText |
Idiopathic Pulmonary Fibrosis (IPF) is a debilitating disease characterized by exaggerated extracellular matrix deposition and aggressive lung structural remodeling. Disease pathogenesis is driven by fibroblastic foci formation, consequent on growth factor overexpression and myofibroblast proliferation. We have previously shown that both CTGF overexpression and myofibroblast formation in IPF cell lines are dependent on RhoA signaling. As RhoA-mediated regulation is also involved in cell cycle progression, we hypothesise that this pathway is key to lung fibroblast turnover through modulation of cyclin D1 kinetic expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-10385618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-10527548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-10572066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-10594038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-10748267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11112140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11177318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11376131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11683383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11696452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11715015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-11734226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-12432268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-12475801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-12775733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-14985071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-14999152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-15298857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-15331580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-15677772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-16354683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-16474852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-7812927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-7971984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-8339933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-9052988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16776827-9552416
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Botulinum Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/exoenzyme C3, Clostridium botulinum,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16776827-ADP Ribose Transferases,
pubmed-meshheading:16776827-Botulinum Toxins,
pubmed-meshheading:16776827-Cell Division,
pubmed-meshheading:16776827-Cell Line,
pubmed-meshheading:16776827-Connective Tissue Growth Factor,
pubmed-meshheading:16776827-Cyclin D1,
pubmed-meshheading:16776827-Fibroblasts,
pubmed-meshheading:16776827-G1 Phase,
pubmed-meshheading:16776827-Gene Expression,
pubmed-meshheading:16776827-Humans,
pubmed-meshheading:16776827-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:16776827-Immediate-Early Proteins,
pubmed-meshheading:16776827-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:16776827-Lung,
pubmed-meshheading:16776827-Pulmonary Fibrosis,
pubmed-meshheading:16776827-Signal Transduction,
pubmed-meshheading:16776827-Simvastatin,
pubmed-meshheading:16776827-Transforming Growth Factor beta,
pubmed-meshheading:16776827-Transforming Growth Factor beta1,
pubmed-meshheading:16776827-Up-Regulation,
pubmed-meshheading:16776827-rhoA GTP-Binding Protein
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pubmed:year |
2006
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pubmed:articleTitle |
RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis.
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pubmed:affiliation |
Lung Research, Institute of Science and Technology in Medicine, University Hospital of North Staffordshire/Keele University, Staffordshire, UK. keira_watts@yahoo.co.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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