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pubmed-article:16775236pubmed:abstractTextInsulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states. Experiments in mice suggest that elevated RBP4 levels cause insulin resistance. We sought to determine whether serum RBP4 levels correlate with insulin resistance and change after an intervention that improves insulin sensitivity. We also determined whether elevated serum RBP4 levels are associated with reduced expression of glucose transporter 4 (GLUT4) in adipocytes, an early pathological feature of insulin resistance.lld:pubmed
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pubmed-article:16775236pubmed:articleTitleRetinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.lld:pubmed
pubmed-article:16775236pubmed:affiliationDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.lld:pubmed
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