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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2006-6-15
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pubmed:abstractText |
Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states. Experiments in mice suggest that elevated RBP4 levels cause insulin resistance. We sought to determine whether serum RBP4 levels correlate with insulin resistance and change after an intervention that improves insulin sensitivity. We also determined whether elevated serum RBP4 levels are associated with reduced expression of glucose transporter 4 (GLUT4) in adipocytes, an early pathological feature of insulin resistance.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:BlüherMatthiasM,
pubmed-author:CiaraldiTheodore PTP,
pubmed-author:GrahamTimothy ETE,
pubmed-author:HammarstedtAnnA,
pubmed-author:HenryRobert RRR,
pubmed-author:JanssonPer-AndersPA,
pubmed-author:KahnBarbara BBB,
pubmed-author:OberbachAndreasA,
pubmed-author:SmithUlfU,
pubmed-author:WasonChristopher JCJ,
pubmed-author:YangQinQ
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pubmed:copyrightInfo |
Copyright 2006 Massachusetts Medical Society.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
354
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2552-63
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16775236-Adipocytes,
pubmed-meshheading:16775236-Adult,
pubmed-meshheading:16775236-Blood Glucose,
pubmed-meshheading:16775236-Cross-Sectional Studies,
pubmed-meshheading:16775236-Diabetes Mellitus, Type 2,
pubmed-meshheading:16775236-Exercise,
pubmed-meshheading:16775236-Female,
pubmed-meshheading:16775236-Glucose Metabolism Disorders,
pubmed-meshheading:16775236-Glucose Transporter Type 4,
pubmed-meshheading:16775236-Humans,
pubmed-meshheading:16775236-Insulin Resistance,
pubmed-meshheading:16775236-Male,
pubmed-meshheading:16775236-Metabolic Syndrome X,
pubmed-meshheading:16775236-Middle Aged,
pubmed-meshheading:16775236-Obesity,
pubmed-meshheading:16775236-Retinol-Binding Proteins,
pubmed-meshheading:16775236-Retinol-Binding Proteins, Plasma,
pubmed-meshheading:16775236-Thinness
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pubmed:year |
2006
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pubmed:articleTitle |
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
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pubmed:affiliation |
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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