Linked Life Data

16774038

Source:http://linkedlifedata.com/resource/pubmed/id/16774038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-6-15
pubmed:abstractText
The Wnt/beta-catenin pathway, with its substantial role in development and disease processes, has been the subject of intensive studies for more than two decades. The multiplicity of protein components in the pathway, with their complicated interactions, phosphorylations, and subcellular localization events, presents itself as a great system for proteomic analysis. Recent advances in proteomic technologies have enabled protein identification and quantification in complex protein mixtures at a global scale, leading to new insights into the pathway. This review will discuss several of the new proteomic technologies, and how they have been applied to the interrogation of the Wnt/beta-catenin pathway, with particular reference to the application of yeast two-hybrid analysis and mass spectrometry-based approaches.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1464-8431
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Proteomic exploration of the Wnt/beta-catenin pathway.
pubmed:affiliation
nstitute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA. qtian@systemsbiology.org
pubmed:publicationType
Journal Article, Review