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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-6-14
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pubmed:abstractText |
The IBD5 locus on chromosome 5q31 is a confirmed Crohn's disease (CD) susceptibility locus in adults. Recently, two polymorphisms in the organic cation transporter (OCTN) gene cluster within the IBD5 locus have been found to be associated with CD. Although the original report of significant linkage to IBD5 was in families with at least one case of early age at onset CD, there are no published reports on the role of OCTN genes in pediatric onset CD. We performed a comprehensive analysis of OCTN variants in an independent, exclusively pediatric onset CD cohort and examined the genotype/phenotype correlations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1354-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16771961-Child,
pubmed-meshheading:16771961-Child, Preschool,
pubmed-meshheading:16771961-Chromosomes, Human, Pair 5,
pubmed-meshheading:16771961-Crohn Disease,
pubmed-meshheading:16771961-Female,
pubmed-meshheading:16771961-Genetic Predisposition to Disease,
pubmed-meshheading:16771961-Genetic Variation,
pubmed-meshheading:16771961-Genotype,
pubmed-meshheading:16771961-Haplotypes,
pubmed-meshheading:16771961-Humans,
pubmed-meshheading:16771961-Infant,
pubmed-meshheading:16771961-Infant, Newborn,
pubmed-meshheading:16771961-Male,
pubmed-meshheading:16771961-Organic Cation Transport Proteins,
pubmed-meshheading:16771961-Phenotype,
pubmed-meshheading:16771961-Polymorphism, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.
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pubmed:affiliation |
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
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pubmed:publicationType |
Journal Article
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