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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-6-14
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pubmed:abstractText |
Mutations in the mismatch repair (MMR) enzymes hMLH1 and hMSH6 are known causes of hereditary nonpolyposis colorectal cancer and act by inducing a mutator phenotype characterized by microsatellite instability. The aim of our study was to determine if polymorphisms in the DNA MMR genes hMLH1 and hMSH6 are associated with an increased risk of colorectal polyps, and to evaluate interactions with exposures known to cause DNA damage.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1313-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16771955-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16771955-Adult,
pubmed-meshheading:16771955-Aged,
pubmed-meshheading:16771955-Base Pair Mismatch,
pubmed-meshheading:16771955-Carrier Proteins,
pubmed-meshheading:16771955-Chi-Square Distribution,
pubmed-meshheading:16771955-Colonic Polyps,
pubmed-meshheading:16771955-DNA Repair,
pubmed-meshheading:16771955-DNA-Binding Proteins,
pubmed-meshheading:16771955-Female,
pubmed-meshheading:16771955-Genetic Predisposition to Disease,
pubmed-meshheading:16771955-Genotype,
pubmed-meshheading:16771955-Haplotypes,
pubmed-meshheading:16771955-Humans,
pubmed-meshheading:16771955-Logistic Models,
pubmed-meshheading:16771955-Male,
pubmed-meshheading:16771955-Middle Aged,
pubmed-meshheading:16771955-Nuclear Proteins,
pubmed-meshheading:16771955-Phenotype,
pubmed-meshheading:16771955-Polymorphism, Genetic,
pubmed-meshheading:16771955-Questionnaires,
pubmed-meshheading:16771955-Risk Factors,
pubmed-meshheading:16771955-Smoking
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pubmed:year |
2006
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pubmed:articleTitle |
Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking.
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pubmed:affiliation |
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109-1024, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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