Source:http://linkedlifedata.com/resource/pubmed/id/16769999
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2006-8-22
|
| pubmed:abstractText |
In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = -0.14 and -0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C>G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For -1131T>C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of -1131T>C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2275
|
| pubmed:author |
pubmed-author:BinghamSheila ASA,
pubmed-author:BoekholdtS MatthijsSM,
pubmed-author:GroenAlbert KAK,
pubmed-author:HattoriHiroakiH,
pubmed-author:HumphriesSteve ESE,
pubmed-author:HuttenBarbara ABA,
pubmed-author:KasteleinJohn J PJJ,
pubmed-author:KhawKay-TeeKT,
pubmed-author:KuivenhovenJan-AlbertJA,
pubmed-author:LubenRobertR,
pubmed-author:PalmenJutta AJA,
pubmed-author:SandhuManjinder SMS,
pubmed-author:SchaapFrank GFG,
pubmed-author:TalmudPhilippa JPJ,
pubmed-author:VaessenStefan F CSF,
pubmed-author:WarehamNicholas JNJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2064-70
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16769999-Aged,
pubmed-meshheading:16769999-Apolipoproteins,
pubmed-meshheading:16769999-Apolipoproteins A,
pubmed-meshheading:16769999-Case-Control Studies,
pubmed-meshheading:16769999-Coronary Artery Disease,
pubmed-meshheading:16769999-Female,
pubmed-meshheading:16769999-Gene Frequency,
pubmed-meshheading:16769999-Genotype,
pubmed-meshheading:16769999-Great Britain,
pubmed-meshheading:16769999-Humans,
pubmed-meshheading:16769999-Linkage Disequilibrium,
pubmed-meshheading:16769999-Male,
pubmed-meshheading:16769999-Middle Aged,
pubmed-meshheading:16769999-Multivariate Analysis,
pubmed-meshheading:16769999-Polymorphism, Single Nucleotide,
pubmed-meshheading:16769999-Prospective Studies,
pubmed-meshheading:16769999-Risk Factors,
pubmed-meshheading:16769999-Triglycerides
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
|
| pubmed:affiliation |
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|