Linked Life Data

16769170

Source:http://linkedlifedata.com/resource/pubmed/id/16769170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-9-26
pubmed:abstractText
It has been shown that small doses of ethanol (<or= 1.0 g/kg) may antagonize the discriminative stimulus properties of nicotine. The aim of the present study was to evaluate whether ethanol could antagonize nicotine's rewarding effects in the conditioned place preference procedure. For comparison, effects of ethanol on nicotine-induced seizures were assessed. Male C57BL/6J mice were used in all experiments. Lower doses of nicotine (0.3 and 0.6 mg/kg, s.c.) induced significant conditioned place preference, while higher doses (0.9 and 1.2 mg/kg) induced neither conditioned place preference nor conditioned place aversion. In the following experiments, ethanol (0.5 or 1.0 g/kg, i.p.) was administered 5 min before 0.3 mg/kg nicotine. Ethanol did not antagonize nicotine-induced conditioned place preference. Contrary to our hypothesis, a non-significant (p = 0.07) enhancement of nicotine-induced place preference conditioning was observed in mice pre-treated with 1.0 g/kg ethanol. Both doses of ethanol (0.5 and 1.0 g/kg) suppressed seizures elicited by a high dose of nicotine (6.0 mg/kg). Ethanol totally eliminated clonic-tonic component of nicotine-induced seizures. Maximal blood ethanol levels after i.p. administration of 0.5 or 1.0 g/kg ethanol exceeded 60 and 115 mg%, respectively. The present results may indicate that the rewarding and seizure-inducing effects of nicotine are differentially modulated by clinically relevant concentrations of ethanol in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1283-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Effects of ethanol on nicotine-induced conditioned place preference in C57BL/6J mice.
pubmed:affiliation
Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957 Warsaw, Poland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't