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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
2006-6-13
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|
pubmed:abstractText |
Although the anti-inflammatory effect of interleukin-1 (IL-1) receptor antagonist (IL-1Ra) has been described, the contribution of this cytokine to non-alcoholic steatohepatitis (NASH) remains unclear. Our aim was to ascertain whether deficiency of IL-1Ra leads to hepatic inflammation and fibrosis upon consumption of an atherogenic diet. IL-1Ra deficient mice (IL-1Ra(-/-)) showed severe steatosis and pericellular fibrosis containing many inflammatory cells following 20 weeks of an atherogenic diet when compared with wild type (WT) mice. The hepatic histology of IL-1Ra(-/-) mice is similar to that of NASH.
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pubmed:language |
jpn
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0047-1852
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
64
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1063-70
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|
pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:16768110-Animals,
pubmed-meshheading:16768110-Diet, Atherogenic,
pubmed-meshheading:16768110-Disease Models, Animal,
pubmed-meshheading:16768110-Fatty Liver,
pubmed-meshheading:16768110-Gene Expression,
pubmed-meshheading:16768110-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:16768110-Lipid Metabolism,
pubmed-meshheading:16768110-Liver,
pubmed-meshheading:16768110-Mice,
pubmed-meshheading:16768110-Receptors, Interleukin-1,
pubmed-meshheading:16768110-Sialoglycoproteins,
pubmed-meshheading:16768110-Signal Transduction
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
[NASH model-- role of interleukin-1 receptor].
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|
pubmed:affiliation |
Department of Internal Medicine, National Defense Medical College.
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|
pubmed:publicationType |
Journal Article,
English Abstract,
Review
|
