Linked Life Data

16768109

Source:http://linkedlifedata.com/resource/pubmed/id/16768109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-6-13
pubmed:abstractText
Mice were fed with control or high fat diet containing approximately 10% or 80% cholesterol, respectively. Macroscopic and microscopic findings demonstrated that lipid accumulation in the liver was observed as early as 2 weeks after high fat diet and that high fat diet for 12 weeks developed a fatty liver phenotype, establishing a novel model of diet-induced liver steatosis. PPARgamma and its targeted gene, CD36 mRNA expression were specifically up-regulated in the liver by high fat diet for 2 weeks. Immunohistochemical study revealed that PPARgamma protein expression is increased in the nuclei of hepatocytes by high fat diet. These results suggest that PPARgamma signaling pathway may be involved in the high fat diet-induced liver steatosis.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1056-61
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Increased expression of PPargamma in fatty liver induced by high fat diet].
pubmed:affiliation
Department of General Medicine, Asahikawa Medical College.
pubmed:publicationType
Journal Article, English Abstract