Source:http://linkedlifedata.com/resource/pubmed/id/16767924
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Suppl
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| pubmed:dateCreated |
2006-6-13
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| pubmed:abstractText |
About 40% of patients bearing a colorectal carcinoma will develop local or distant tumor recurrences. Integrated analyses of biopathological markers, predictive of tumor aggressiveness, may offer a more rational approach to adjuvant therapy planning. To this end we analyzed the correlation between p53 accumulation, bcl-2 expression with cell proliferation, DNA ploidy, and conventional histological parameters, by testing the prognostic significance of these variables in a series of 214 patients bearing a colorectal carcinoma. When these parameters were examined in the univariate analysis, significantly shorter disease free and overall survival were observed in patients bearing p53+ and bcl-2- tumors. In the multivariate analysis p53 accumulation and bcl-2 expression emerged as independent predictors respectively of worse and better clinical outcome also in Dukes' B stage identifying patients at higher risk to develop liver metastases.. These results indicate that in colorectal adenocarcinomas a biological profile, based on the combined evaluation of p53 and bcl-2, can be useful in identifying high risk patients to be enrolled in an adjuvant setting mainly in early stage of the disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0392-9078
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
163-6
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| pubmed:meshHeading |
pubmed-meshheading:16767924-Adenocarcinoma,
pubmed-meshheading:16767924-Aged,
pubmed-meshheading:16767924-Cell Proliferation,
pubmed-meshheading:16767924-Colorectal Neoplasms,
pubmed-meshheading:16767924-Disease-Free Survival,
pubmed-meshheading:16767924-Female,
pubmed-meshheading:16767924-Humans,
pubmed-meshheading:16767924-Immunohistochemistry,
pubmed-meshheading:16767924-Liver Neoplasms,
pubmed-meshheading:16767924-Male,
pubmed-meshheading:16767924-Middle Aged,
pubmed-meshheading:16767924-Ploidies,
pubmed-meshheading:16767924-Prognosis,
pubmed-meshheading:16767924-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16767924-Survival Analysis,
pubmed-meshheading:16767924-Survival Rate,
pubmed-meshheading:16767924-Tumor Markers, Biological,
pubmed-meshheading:16767924-Tumor Suppressor Protein p53
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| pubmed:year |
2003
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| pubmed:articleTitle |
Bio-pathological factors of prognostic value in colorectal adenocarcinomas.
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| pubmed:affiliation |
Pathology Department, Regina Elena Cancer Institute, Rome, Italy. mottolese@crs.ifo.it
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| pubmed:publicationType |
Journal Article
|