Source:http://linkedlifedata.com/resource/pubmed/id/16766182
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
2006-9-6
|
| pubmed:abstractText |
The design and synthesis of a series of potent 1,3,4-trisubstituted-2-oxopiperazine based MC4 agonists are described. The tripeptidomimetic analogs (12a,b and 23) and the dipeptidomimetic 27 displayed single-nanomolar binding affinity and agonist potency for MC4R and excellent selectivity for MC4R relative to MC1R.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:CrossdoersenDoreenD,
pubmed-author:EbetinoFrank HFH,
pubmed-author:FarmerJulie AJA,
pubmed-author:HuX EricXE,
pubmed-author:KimNickN,
pubmed-author:MazurAdam WAW,
pubmed-author:MishraRajesh KRK,
pubmed-author:PinneyBeth BBB,
pubmed-author:SheldonRussell JRJ,
pubmed-author:SwitzerAdrian GAG,
pubmed-author:TianXinrongX,
pubmed-author:WosJohn AJA
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4668-73
|
| pubmed:meshHeading | |
| pubmed:year |
2006
|
| pubmed:articleTitle |
Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.
|
| pubmed:affiliation |
Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. tian.x@hotmail.com
|
| pubmed:publicationType |
Journal Article
|