Source:http://linkedlifedata.com/resource/pubmed/id/16765543
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2006-8-28
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| pubmed:abstractText |
The transformation kinetics of mefenamic acid form II to form I in three kinds of solvents and under high humidity conditions were extensively investigated. Form II crystals were suspended in water, 50% ethanol and ethanol at 28, 33 and 37 degrees C, or stored at 50, 60 and 70 degrees C at 97% RH. Form II transformed to form I under all storage conditions and the rate of transformation depended on the kind of solvent. The transformation followed the three-dimensional nuclei growth mechanism, depending on temperature. The nuclei formation and growth processes were significantly accelerated in ethanol compared with water. The addition of seed crystals of the stable form I shortened the both nuclei formation and growth processes and therefore the transformation was accelerated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0378-5173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
14
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| pubmed:volume |
321
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
18-26
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| pubmed:meshHeading | |
| pubmed:year |
2006
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| pubmed:articleTitle |
Kinetic study of the transformation of mefenamic acid polymorphs in various solvents and under high humidity conditions.
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| pubmed:affiliation |
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658-8558, Japan. f-katoh@kobepharma-u.ac.jp
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| pubmed:publicationType |
Journal Article
|