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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5015
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pubmed:dateCreated |
1991-8-2
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pubmed:databankReference |
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pubmed:abstractText |
Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
253
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pubmed:geneSymbol |
Hlx,
TLC3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-82
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1676542-Amino Acid Sequence,
pubmed-meshheading:1676542-Animals,
pubmed-meshheading:1676542-Base Sequence,
pubmed-meshheading:1676542-Blotting, Northern,
pubmed-meshheading:1676542-Chromosomes, Human, Pair 10,
pubmed-meshheading:1676542-Chromosomes, Human, Pair 14,
pubmed-meshheading:1676542-Cloning, Molecular,
pubmed-meshheading:1676542-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:1676542-Genes, Homeobox,
pubmed-meshheading:1676542-Humans,
pubmed-meshheading:1676542-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:1676542-Mice,
pubmed-meshheading:1676542-Molecular Sequence Data,
pubmed-meshheading:1676542-Receptors, Antigen, T-Cell,
pubmed-meshheading:1676542-Restriction Mapping,
pubmed-meshheading:1676542-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1676542-Translocation, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.
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pubmed:affiliation |
Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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