|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0021469,
umls-concept:C0185117,
umls-concept:C0332206,
umls-concept:C1280500,
umls-concept:C1514485,
umls-concept:C1518174,
umls-concept:C1569674,
umls-concept:C2239176,
umls-concept:C2911684
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-6-12
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|
pubmed:abstractText |
Human augmenter of liver regeneration (hALR) is highly expressed in hepatocellular carcinoma (HCC), but rarely expressed in normal liver cells. ALR could stimulate the proliferation of HCC cell line in vitro, but has no effect on normal hepatocytes. This study was to investigate the inhibitory effect of blocking the expression of hALR on the proliferation of HCC cell line HepG2 using small interfering RNA (siRNA) targeting ALR and anti-ALR monoclonal antibody (McAb).
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|
pubmed:language |
chi
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1000-467X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
671-6
|
|
pubmed:meshHeading |
pubmed-meshheading:16764759-Antibodies, Monoclonal,
pubmed-meshheading:16764759-Carcinoma, Hepatocellular,
pubmed-meshheading:16764759-Cell Line, Tumor,
pubmed-meshheading:16764759-Cell Proliferation,
pubmed-meshheading:16764759-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16764759-Green Fluorescent Proteins,
pubmed-meshheading:16764759-Humans,
pubmed-meshheading:16764759-Liver Neoplasms,
pubmed-meshheading:16764759-Plasmids,
pubmed-meshheading:16764759-Proteins,
pubmed-meshheading:16764759-RNA, Messenger,
pubmed-meshheading:16764759-RNA, Small Interfering,
pubmed-meshheading:16764759-RNA Interference,
pubmed-meshheading:16764759-Recombinant Proteins,
pubmed-meshheading:16764759-Transfection
|
|
pubmed:year |
2006
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|
pubmed:articleTitle |
[Inhibitory effect of blocking expression of human augmenter of liver regeneration (hALR) on proliferation of hepatocellular carcinoma cell line HepG2].
|
|
pubmed:affiliation |
Laboratory of Molecular Biology for Infectious Disease, Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing, 400010, P. R. China.
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|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|
