Linked Life Data

16764738

Source:http://linkedlifedata.com/resource/pubmed/id/16764738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2006-6-12
pubmed:abstractText
The Rhesus (Rh) blood group system is expressed by a pair of 12-transmembrane-domain-containing proteins, the RhCcEe and RhD proteins. RhCcEe and RhD associate as a Rh core complex that comprises one RhD/CcEe protein and most likely two Rh-associated glycoproteins (RhAG) as a trimer. All these Rh proteins are homologous and share this homology with two human non-erythroid proteins, RhBG and RhCG. All Rh protein superfamily members share homology and function in a similar manner to the Mep/Amt ammonium transporters, which are highly conserved in bacteria, plants and invertebrates. Significant advances have been made in our understanding of the structure and function of Rh proteins, as well as in the clinical management of Rh haemolytic disease. This review summarises our current knowledge concerning the molecular biology of Rh proteins and their role in transfusion and pregnancy incompatibility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1462-3994
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-20
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Molecular biology of Rh proteins and relevance to molecular medicine.
pubmed:affiliation
Centre for Research in Biomedicine and Genomics Research Institute, University of the West of England, Coldharbour Lane, Frenchay, Bristol, BS16 1QY, UK. neil.avent@uwe.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't