rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-8-6
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pubmed:abstractText |
The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic surrogates for the catechol moiety of dopamine. Compound 4b from this series showed a biochemical profile that translated to behavioral activity in the rat predictive of an antipsychotic agent with a low propensity to cause extrapyramidal side effects in man.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(1-naphthyl)piperazine,
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Amphetamines,
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Haloperidol,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1860-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1676427-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:1676427-Amphetamines,
pubmed-meshheading:1676427-Animals,
pubmed-meshheading:1676427-Antipsychotic Agents,
pubmed-meshheading:1676427-Apomorphine,
pubmed-meshheading:1676427-Autoradiography,
pubmed-meshheading:1676427-Behavior, Animal,
pubmed-meshheading:1676427-Dopamine Antagonists,
pubmed-meshheading:1676427-Haloperidol,
pubmed-meshheading:1676427-Ketanserin,
pubmed-meshheading:1676427-Locomotion,
pubmed-meshheading:1676427-Male,
pubmed-meshheading:1676427-Piperazines,
pubmed-meshheading:1676427-Prazosin,
pubmed-meshheading:1676427-Rats,
pubmed-meshheading:1676427-Rats, Inbred Strains,
pubmed-meshheading:1676427-Structure-Activity Relationship,
pubmed-meshheading:1676427-Tetrahydronaphthalenes
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pubmed:year |
1991
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pubmed:articleTitle |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
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pubmed:affiliation |
Central Research Division, Pfizer, Inc., Groton, Connecticut 06340.
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pubmed:publicationType |
Journal Article
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