Linked Life Data

1676316

Source:http://linkedlifedata.com/resource/pubmed/id/1676316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-8-5
pubmed:abstractText
The effect of 24 h food deprivation on endotoxin (ET) lethality in SpD rats was studied. Fed and fasted animals received either 6 h i.v. infusions or i.p. boluses of ET at low, intermediate and high doses, and survival for seven days observed. Fasting was associated with 208-240% greater mortality when ET was infused i.v., and 87-200% when given i.p. ET doses LD10-LD80 gave a linear relationship with mortality. In non-fasted control rats liver glycogen content reduced by 1.28 mumols/min/g dry liver wt over the first post-prandial six hours, and increased by 65-99% in a dose dependent manner after ET (p less than 0.01). Evidence was also obtained relating both liver damage (assessed blind by histopathological scoring) and leucopenia with endotoxin dose, results which were modified by nutritional status. The evidence supports the role of liver glycogen as a protective substrate resource in endotoxic shock.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1102-4151
pubmed:author
pubmed:issnType
Print
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Twenty-four hour fasting increases endotoxin lethality in the rat.
pubmed:affiliation
Department of Surgery, University Hospital, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't