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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5779
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pubmed:dateCreated |
2006-6-9
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pubmed:abstractText |
Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-10482571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-10590091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-10684290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-11039923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-11393868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-11739694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-11797011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-14645590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15220422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15297611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15660510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15709015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15793563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15795244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15814700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-15858035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-16107946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-16107949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-16306625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-8638160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-9371613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763152-9847367
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BarkerBrianne RBR,
pubmed-author:BooksteinFred LFL,
pubmed-author:BuzbyAdam PAP,
pubmed-author:ChakrabartiBimalB,
pubmed-author:GorgoneDarci ADA,
pubmed-author:LetvinNorman LNL,
pubmed-author:LingXuX,
pubmed-author:MascolaJohn RJR,
pubmed-author:MontefioriDavid CDC,
pubmed-author:NabelGary JGJ,
pubmed-author:RaoSrinivas SSS,
pubmed-author:SchmitzJörn EJE,
pubmed-author:SunYueY,
pubmed-author:YangZhi-YongZY
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
312
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1530-3
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:16763152-Amino Acid Sequence,
pubmed-meshheading:16763152-Animals,
pubmed-meshheading:16763152-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16763152-Humans,
pubmed-meshheading:16763152-Immunologic Memory,
pubmed-meshheading:16763152-Macaca mulatta,
pubmed-meshheading:16763152-Molecular Sequence Data,
pubmed-meshheading:16763152-Plasmids,
pubmed-meshheading:16763152-SAIDS Vaccines,
pubmed-meshheading:16763152-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16763152-Simian immunodeficiency virus,
pubmed-meshheading:16763152-Survival Analysis,
pubmed-meshheading:16763152-Vaccines, DNA,
pubmed-meshheading:16763152-Vaccines, Synthetic,
pubmed-meshheading:16763152-Virus Replication
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pubmed:year |
2006
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pubmed:articleTitle |
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
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pubmed:affiliation |
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. nletvin@bidmc.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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