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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5783
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pubmed:dateCreated |
2006-7-7
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pubmed:abstractText |
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Bni1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/CDC5 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RHO1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/ROM2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TUS1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
313
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
108-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16763112-Actins,
pubmed-meshheading:16763112-Amino Acid Motifs,
pubmed-meshheading:16763112-Anaphase,
pubmed-meshheading:16763112-Cell Cycle Proteins,
pubmed-meshheading:16763112-Cytokinesis,
pubmed-meshheading:16763112-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:16763112-Guanosine Triphosphate,
pubmed-meshheading:16763112-Microfilament Proteins,
pubmed-meshheading:16763112-Mitosis,
pubmed-meshheading:16763112-Mutation,
pubmed-meshheading:16763112-Phosphorylation,
pubmed-meshheading:16763112-Protein Kinases,
pubmed-meshheading:16763112-Recombinant Fusion Proteins,
pubmed-meshheading:16763112-Saccharomyces cerevisiae,
pubmed-meshheading:16763112-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:16763112-Temperature,
pubmed-meshheading:16763112-rho GTP-Binding Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.
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pubmed:affiliation |
Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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