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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-8-2
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pubmed:abstractText |
Reclustering and indirect immunofluorescence assays on MT-4 cells [carrying both CD4 and complement receptor type 2 (CR2)] were used to measure neutralizing and enhancing antibodies in sera obtained from HIV-1-infected individuals. Heat-inactivated sera were tested before and after mixing 1:1 with fresh seronegative human serum. Using heated samples, neutralizing antibodies were found in 20 out of 20 and 11 out of 19 serum samples of asymptomatic and symptomatic [AIDS, AIDS-related complex (ARC)] HIV-seropositive patients, respectively. In complement-restored samples, neutralizing activity was found in eight sera of asymptomatic patients and in none of the sera of AIDS and ARC patients; enhancing activity could be detected in four and 12 sera, respectively. A significant positive correlation was observed between the titres of neutralizing antibodies measured in the complement-restored samples and the absolute number of CD4+ lymphocytes. These findings indicate that the appearance of complement-dependent enhancing antibodies coincident with the loss of neutralizing antibodies may indicate a poor prognosis in HIV infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1676275-AIDS-Related Complex,
pubmed-meshheading:1676275-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1676275-Antigens, CD4,
pubmed-meshheading:1676275-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1676275-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1676275-Cell Line,
pubmed-meshheading:1676275-Complement System Proteins,
pubmed-meshheading:1676275-HIV Antibodies,
pubmed-meshheading:1676275-HIV Infections,
pubmed-meshheading:1676275-HIV Seropositivity,
pubmed-meshheading:1676275-HIV-1,
pubmed-meshheading:1676275-Humans,
pubmed-meshheading:1676275-Leukocyte Count,
pubmed-meshheading:1676275-Neutralization Tests,
pubmed-meshheading:1676275-Receptors, Complement,
pubmed-meshheading:1676275-Receptors, Complement 3d,
pubmed-meshheading:1676275-T-Lymphocyte Subsets
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pubmed:year |
1991
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pubmed:articleTitle |
Neutralizing and complement-dependent enhancing antibodies in different stages of HIV infection.
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pubmed:affiliation |
Institute of Microbiology, University Medical School, Debrecen, Hungary.
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pubmed:publicationType |
Journal Article,
Comparative Study
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