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rdf:type |
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lifeskim:mentions |
umls-concept:C0030956,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0242402,
umls-concept:C0243077,
umls-concept:C0382336,
umls-concept:C0456387,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C1417756,
umls-concept:C1420220,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
16
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pubmed:dateCreated |
2006-7-17
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pubmed:abstractText |
A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1 inhibitors. The molecules are devoid of activity at the GlyT2 isoform and display excellent selectivities against the mu opioid receptor as well as the nociceptin/orphanin FQ peptide (NOP) receptor. A novel, straightforward and efficient synthetic strategy for the assembly of the target molecules is also presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/G Protein-Coupled...,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Opioid Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/nociceptin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AlberatiDanielaD,
pubmed-author:CeccarelliSimona MSM,
pubmed-author:JolidonSynèseS,
pubmed-author:KrafftEva AEA,
pubmed-author:KurtAnkeA,
pubmed-author:MaierAxelA,
pubmed-author:PinardEmmanuelE,
pubmed-author:StalderHenriH,
pubmed-author:StuderDeborahD,
pubmed-author:ThomasAndrew WAW,
pubmed-author:ZimmerliDanielD
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4305-10
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pubmed:meshHeading |
pubmed-meshheading:16762548-G Protein-Coupled Inwardly-Rectifying Potassium Channels,
pubmed-meshheading:16762548-Glycine Plasma Membrane Transport Proteins,
pubmed-meshheading:16762548-Humans,
pubmed-meshheading:16762548-Inhibitory Concentration 50,
pubmed-meshheading:16762548-Models, Chemical,
pubmed-meshheading:16762548-Opioid Peptides,
pubmed-meshheading:16762548-Peptides,
pubmed-meshheading:16762548-Protein Isoforms,
pubmed-meshheading:16762548-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:16762548-Receptors, Opioid,
pubmed-meshheading:16762548-Stereoisomerism,
pubmed-meshheading:16762548-X-Rays
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pubmed:year |
2006
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pubmed:articleTitle |
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.
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pubmed:affiliation |
Discovery Biology, F. Hoffmann-La Roche Ltd, Pharmaceuticals Division, Switzerland.
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pubmed:publicationType |
Journal Article
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