Source:http://linkedlifedata.com/resource/pubmed/id/16760913
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-7-13
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| pubmed:abstractText |
Treatment of organ donors with catecholamines reduces acute rejection episodes and improves long-term graft survival after renal transplantation. The aim of this study was to investigate the effect of catecholamine pre-treatment on ischemia/reperfusion (I/R)- and cold preservation injury in rat kidneys. I/R-injury was induced by clamping the left kidney vessels for 60 min along with a contralateral nephrectomy. Cold preservation injury was induced by storage of the kidneys for 24 h at +4 degrees Celsius in University of Wisconsin solution, followed by syngeneic transplantation. Rats were pre-treated with either dopamine (DA), dobutamine (DB), or norepinephrine (2, 5, and 10 microg/kg/min, each group) intravenously via an osmotic minipump for 24 h before I/R- and cold preservation injury. Pre-treatment with DA (2 or 5 microg/kg/min) and DB (5 microg/kg/min) improved recovery of renal function after I/R-injury and dose dependently reduced mononuclear and major histocompatibility complex class II-positive cells infiltrating the kidney after I/R-injury. One day after I/R-injury, upregulation of transforming growth factor (TGF)-beta 1 and 2 and phosphorylation of p42/p44 mitogen-activated protein kinases was observed in kidneys of animals treated with DA or DB. DA (5 microg/kg/min) and DB (5 microg/kg/min) pre-treatment reduced endothelial cell damage after 24 h of cold preservation. Only DA pre-treatment improved renal function and reduced renal inflammation after 24 h of cold preservation and syngeneic transplantation. Our results demonstrate a protective effect of pre-treatment with catecholamines on renal inflammation and function after I/R- or cold preservation injury. This could help to explain the potent organoprotective effects of catecholamine pre-treatment observed in human kidney transplantation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Dobutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Sympathomimetics
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0085-2538
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
70
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
321-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16760913-Animals,
pubmed-meshheading:16760913-Catecholamines,
pubmed-meshheading:16760913-Cold Temperature,
pubmed-meshheading:16760913-Cryopreservation,
pubmed-meshheading:16760913-Dobutamine,
pubmed-meshheading:16760913-Dopamine,
pubmed-meshheading:16760913-Dopamine Agents,
pubmed-meshheading:16760913-Graft Survival,
pubmed-meshheading:16760913-Ischemic Preconditioning,
pubmed-meshheading:16760913-Kidney,
pubmed-meshheading:16760913-Kidney Transplantation,
pubmed-meshheading:16760913-Male,
pubmed-meshheading:16760913-Nephrectomy,
pubmed-meshheading:16760913-Norepinephrine,
pubmed-meshheading:16760913-Rats,
pubmed-meshheading:16760913-Rats, Inbred Lew,
pubmed-meshheading:16760913-Reperfusion Injury,
pubmed-meshheading:16760913-Sympathomimetics
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| pubmed:year |
2006
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| pubmed:articleTitle |
Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats.
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| pubmed:affiliation |
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Hospital Mannheim, University of Heidelberg, Mannheim, Germany. uwe.goettmann@med5.ma.uni-heidelberg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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