Source:http://linkedlifedata.com/resource/pubmed/id/16759729
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-6-19
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| pubmed:abstractText |
In this study, we examined changes in the level and immunoreactivity of alpha-synuclein in the hippocampal CA1 region of adult (6 months old) and aged (24 months old) gerbils after 5 min of transient forebrain ischemia. The delayed neuronal death of CA1 pyramidal cells in adult gerbils was severer than that in aged gerbils 4 days after ischemia/reperfusion. Alpha-synuclein immunoreactivity in the CA1 region of adult and aged gerbils significantly changed after ischemia. In control animals, alpha-synuclein immunoreactivity and level in the aged-gerbil CA1 region were higher than those in the adult-gerbil CA1 region. In both adult and aged gerbils, alpha-synuclein immunoreactivity and level started to increase 3h after ischemia, and they were highest 1 day after ischemia. Thereafter, alpha-synuclein immunoreactivity and level decreased with time after ischemia. We also observed the effects of Cu,Zn-superoxide dismutase (SOD1) on ischemic damage using the Pep-1 transduction domain. Alpha-synuclein level in the CA1 region was lower in Pep-1-SOD1-treated adult and aged gerbils than in vehicle-treated adult and aged gerbils. We conclude that neuronal loss in the hippocampal CA1 region of adult gerbils was more prominent than that in aged gerbils 4 days after ischemia/reperfusion. The higher level of alpha-synuclein in the aged-gerbil CA1 region than that in the adult-gerbil CA1 region may be associated with the earlier induction of reactive oxygen species, and Pep-1-SOD1 potentially and reversibly inhibits the accumulation of alpha-synuclein in the CA1 region after transient ischemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0168-0102
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
434-41
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16759729-Aging,
pubmed-meshheading:16759729-Animals,
pubmed-meshheading:16759729-Brain Ischemia,
pubmed-meshheading:16759729-Cell Death,
pubmed-meshheading:16759729-Disease Models, Animal,
pubmed-meshheading:16759729-Down-Regulation,
pubmed-meshheading:16759729-Gerbillinae,
pubmed-meshheading:16759729-Hippocampus,
pubmed-meshheading:16759729-Immunohistochemistry,
pubmed-meshheading:16759729-Male,
pubmed-meshheading:16759729-Nerve Degeneration,
pubmed-meshheading:16759729-Protein Structure, Tertiary,
pubmed-meshheading:16759729-Pyramidal Cells,
pubmed-meshheading:16759729-Reactive Oxygen Species,
pubmed-meshheading:16759729-Reperfusion Injury,
pubmed-meshheading:16759729-Superoxide Dismutase,
pubmed-meshheading:16759729-Time Factors,
pubmed-meshheading:16759729-alpha-Synuclein
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| pubmed:year |
2006
|
| pubmed:articleTitle |
Comparison of alpha-synuclein immunoreactivity and protein levels in ischemic hippocampal CA1 region between adult and aged gerbils and correlation with Cu,Zn-superoxide dismutase.
|
| pubmed:affiliation |
Department of Surgery, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|