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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-6-8
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pubmed:abstractText |
We analysed viral kinetics from a 2-day treatment with BILN 2061, a serine protease inhibitor of hepatitis C virus, in patients chronically infected with genotype 1 hepatitis C virus. The efficiency (E), describing inhibition of viral production, was above 99.45% in all patients with minor or moderate fibrosis receiving doses of 200mg and 500 mg twice daily and larger than in previous studies for interferon-based treatments. However, epsilon was slightly smaller in patients with cirrhosis given 200mg and markedly smaller in patients given 25 mg. Estimates of viral clearance and infected-cell loss support conclusions on these rates and on treatment mechanisms from previous studies on interferon-alpha-based treatments.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1359-6535
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pubmed:author |
pubmed-author:BenhamouYvesY,
pubmed-author:CallejaJosé LJL,
pubmed-author:FornsXavierX,
pubmed-author:HerrmannEvaE,
pubmed-author:HinrichsenHolgerH,
pubmed-author:MannsMichael PMP,
pubmed-author:NehmizGerhardG,
pubmed-author:ReesinkHenkH,
pubmed-author:ReiserMarkusM,
pubmed-author:SarrazinChristophC,
pubmed-author:SteinmannGerhard GGG,
pubmed-author:ZeuzemStefanS
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
371-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16759054-Adult,
pubmed-meshheading:16759054-Antiviral Agents,
pubmed-meshheading:16759054-Area Under Curve,
pubmed-meshheading:16759054-Carbamates,
pubmed-meshheading:16759054-Female,
pubmed-meshheading:16759054-Hepacivirus,
pubmed-meshheading:16759054-Hepatitis C, Chronic,
pubmed-meshheading:16759054-Humans,
pubmed-meshheading:16759054-Interferon-alpha,
pubmed-meshheading:16759054-Kinetics,
pubmed-meshheading:16759054-Macrocyclic Compounds,
pubmed-meshheading:16759054-Male,
pubmed-meshheading:16759054-Middle Aged,
pubmed-meshheading:16759054-Models, Biological,
pubmed-meshheading:16759054-Quinolines,
pubmed-meshheading:16759054-RNA, Viral,
pubmed-meshheading:16759054-Serine Proteinase Inhibitors,
pubmed-meshheading:16759054-Thiazoles
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pubmed:year |
2006
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pubmed:articleTitle |
Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061.
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pubmed:affiliation |
Medizinische Klinik und Poliklinik, Innere Medizin II, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany. Eva.Herrmann@Uniklinikum-Saarland.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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