|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0014921,
umls-concept:C0015133,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205195,
umls-concept:C0600139,
umls-concept:C1122861,
umls-concept:C1280500,
umls-concept:C1513016,
umls-concept:C1710493,
umls-concept:C2349975
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pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-11-30
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|
pubmed:abstractText |
Therapeutic efficacy of the novel matrix metalloproteinase (MMP) inhibitor Ro 28-2653 has been shown in various models of different tumor entities. We hypothesized that the inhibitor effect of Ro 28-2653 on the tumor growth could be improved by combination with chemotherapeutic drugs and examined therefore the effect of Ro 28-2653 alone and in combination with etoposide or estramustine in the MatLyLu Dunning R-3327 rat tumor model characteristic for the androgen-independent prostate cancer (PCa).
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0344-5704
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-82
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pubmed:meshHeading |
pubmed-meshheading:16758188-Animals,
pubmed-meshheading:16758188-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16758188-Body Weight,
pubmed-meshheading:16758188-Cell Line, Tumor,
pubmed-meshheading:16758188-Cell Proliferation,
pubmed-meshheading:16758188-Disease Models, Animal,
pubmed-meshheading:16758188-Drug Resistance, Neoplasm,
pubmed-meshheading:16758188-Drug Screening Assays, Antitumor,
pubmed-meshheading:16758188-Drug Synergism,
pubmed-meshheading:16758188-Estramustine,
pubmed-meshheading:16758188-Etoposide,
pubmed-meshheading:16758188-Humans,
pubmed-meshheading:16758188-Injections, Intraperitoneal,
pubmed-meshheading:16758188-Male,
pubmed-meshheading:16758188-Neoplasm Invasiveness,
pubmed-meshheading:16758188-Neoplasm Transplantation,
pubmed-meshheading:16758188-Piperazines,
pubmed-meshheading:16758188-Prostatic Neoplasms,
pubmed-meshheading:16758188-Pyrimidines,
pubmed-meshheading:16758188-Rats,
pubmed-meshheading:16758188-Time Factors,
pubmed-meshheading:16758188-Tissue Inhibitor of Metalloproteinases
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|
pubmed:year |
2007
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pubmed:articleTitle |
Enhanced inhibitory effect of the matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine and etoposide on the prostate carcinoma in the rat Dunning orthotopic tumor model.
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pubmed:affiliation |
Department of Urology, University Hospital Charité, Humboldt University, Schumannstrasse 20/21, 10098, Berlin, Germany.
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pubmed:publicationType |
Journal Article
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