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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-6-7
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pubmed:abstractText |
Immune responses require costimulatory interactions between molecules on antigen-presenting cells and T cells: CD40 binding to CD40 ligand and B7 binding to CD28. Graves' hyperthyroidism is induced in BALB/c mice by immunization with thyrotropin receptor (TSHR) A-subunit adenovirus (Ad-A-subunit). We attempted to modulate Ad-A-subunit-induced Graves' disease using adenoviruses expressing costimulation "decoys": CD40-IgG-Fc (CD40-Ig) to block CD40:CD40-ligand interactions and CTLA4-Fc (CTLA4-Ig) to prevent B7:CD28 binding.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1050-7256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16756463-Adenoviridae,
pubmed-meshheading:16756463-Animals,
pubmed-meshheading:16756463-Antigen-Presenting Cells,
pubmed-meshheading:16756463-Antigens, CD28,
pubmed-meshheading:16756463-Antigens, CD40,
pubmed-meshheading:16756463-CD40 Ligand,
pubmed-meshheading:16756463-Disease Models, Animal,
pubmed-meshheading:16756463-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16756463-Female,
pubmed-meshheading:16756463-Graves Disease,
pubmed-meshheading:16756463-Hyperthyroidism,
pubmed-meshheading:16756463-Mice,
pubmed-meshheading:16756463-Mice, Inbred BALB C,
pubmed-meshheading:16756463-Models, Biological,
pubmed-meshheading:16756463-Protein Binding,
pubmed-meshheading:16756463-Receptors, Thyrotropin,
pubmed-meshheading:16756463-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus.
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pubmed:affiliation |
Autoimmune Disease Unit, Cedars-Sinai Research Institute and UCLA School of Medicine, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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