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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2006-6-7
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pubmed:abstractText |
Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment (Trp9-Pro18) passes through the ring segment (Gly1-Glu8) to form a 'lasso' structure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-7863
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7486-91
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pubmed:meshHeading |
pubmed-meshheading:16756302-Amino Acid Sequence,
pubmed-meshheading:16756302-Animals,
pubmed-meshheading:16756302-Anti-Bacterial Agents,
pubmed-meshheading:16756302-Glutamic Acid,
pubmed-meshheading:16756302-Glycine,
pubmed-meshheading:16756302-Magnetic Resonance Spectroscopy,
pubmed-meshheading:16756302-Molecular Sequence Data,
pubmed-meshheading:16756302-Molecular Structure,
pubmed-meshheading:16756302-Peptides, Cyclic,
pubmed-meshheading:16756302-Proline,
pubmed-meshheading:16756302-Rhodococcus,
pubmed-meshheading:16756302-Tryptophan
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pubmed:year |
2006
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pubmed:articleTitle |
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure.
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pubmed:affiliation |
Kitasato Institute, Kitasato University, Minato-ku, Tokyo 108, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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