Linked Life Data

16755582

Source:http://linkedlifedata.com/resource/pubmed/id/16755582

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-9-27
pubmed:abstractText
Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0885-3185
pubmed:author
pubmed:copyrightInfo
(c) 2006 Movement Disorder Society.
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1317-25
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:16755582-Adult, pubmed-meshheading:16755582-Atrophy, pubmed-meshheading:16755582-Basal Ganglia, pubmed-meshheading:16755582-Brain, pubmed-meshheading:16755582-Cerebral Cortex, pubmed-meshheading:16755582-Corpus Callosum, pubmed-meshheading:16755582-Diffusion Magnetic Resonance Imaging, pubmed-meshheading:16755582-Early Diagnosis, pubmed-meshheading:16755582-Extrapyramidal Tracts, pubmed-meshheading:16755582-Female, pubmed-meshheading:16755582-Frontal Lobe, pubmed-meshheading:16755582-Humans, pubmed-meshheading:16755582-Huntington Disease, pubmed-meshheading:16755582-Image Processing, Computer-Assisted, pubmed-meshheading:16755582-Internal Capsule, pubmed-meshheading:16755582-Male, pubmed-meshheading:16755582-Middle Aged, pubmed-meshheading:16755582-Nerve Fibers, Myelinated, pubmed-meshheading:16755582-Neural Pathways, pubmed-meshheading:16755582-Neurologic Examination, pubmed-meshheading:16755582-Neuropsychological Tests, pubmed-meshheading:16755582-Parietal Lobe, pubmed-meshheading:16755582-Pyramidal Tracts
pubmed:year
2006
pubmed:articleTitle
Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures.
pubmed:affiliation
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. rosas@helix.mgh.harvard.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural