Linked Life Data

16755539

Source:http://linkedlifedata.com/resource/pubmed/id/16755539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-28
pubmed:abstractText
Diffusion tensor imaging (DTI) accurately delineates white matter pathways when the Gaussian model of diffusion is valid. However, DTI yields erroneous results when diffusion takes on a more complex distribution, as is the case in the brain when fiber tracts cross. High angular resolution diffusion imaging (HARDI) overcomes this limitation of DTI by more fully characterizing the angular dependence of intravoxel diffusion. Among the various HARDI methods that have been proposed, QBI offers advantages such as linearity, model independence, and relatively easy implementation. In this work, reconstruction of the q-ball orientation distribution function (ODF) is reformulated in terms of spherical harmonic basis functions, yielding an analytic solution with useful properties of a frequency domain representation. The harmonic basis is parsimonious for typical b-values, which enables the ODF to be synthesized from a relatively small number of noisy measurements and thus brings the technique closer to clinical feasibility from the standpoint of total imaging time. The proposed method is assessed using Monte Carlo computer simulations and compared with conventional q-ball reconstruction using spherical RBFs. In vivo results from 3T whole-brain HARDI of adult volunteers are also provided to verify the underlying mathematical theory.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0740-3194
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-17
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Q-ball reconstruction of multimodal fiber orientations using the spherical harmonic basis.
pubmed:affiliation
Department of Radiology, University of California-San Francisco, San Francisco, California 94143-0628, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural